Una mutazione genetica rarissima ha reso una donna insensibile al dolore, all’ansia e persino alla paura. Ma non è un superpotere: è un enigma biologico.
Introduzione
Jo Cameron ha vissuto per decenni senza sapere di essere “diversa”. Nessun mal di testa, nessuna fitta, nessuna ansia prima di un intervento chirurgico. Solo dopo una operazione alla mano i medici si sono accorti che qualcosa non tornava: non provava dolore, né paura, né stress.
Gli studi genetici hanno rivelato una mutazione nel gene FAAH-OUT, un regolatore del sistema endocannabinoide. Questo gene, normalmente silenzioso, in lei è attivo e interferisce con la percezione del dolore e delle emozioni negative.
Curiosità scientifica
– Il gene FAAH è coinvolto nella degradazione degli endocannabinoidi, molecole che regolano dolore, umore e memoria.
– La mutazione di Jo Cameron riduce l’attività di FAAH, aumentando la presenza di molecole “antidolorifiche” naturali.
– I ricercatori sperano di potere imitare questa mutazione per sviluppare nuovi farmaci contro il dolore cronico e l’ansia.
Conclusione INCREDIBILE
La storia di Jo Cameron non è solo una curiosità genetica. È una finestra su un futuro in cui potremmo modulare il dolore senza oppioidi, e trattare l’ansia e la paura con precisione molecolare; tuttavia la sua storia ci ricorda anche che il dolore, per quanto scomodo, è spesso una bussola vitale.
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